PLAUR (Human) Recombinant Protein
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Specifications
Product Description
Purified PLAUR (NP_002650.1 23 a.a. - 350 a.a.) human recombinant protein with His-Flag-StrepII tag at C-terminus expressed in human cells.
Transfected Cell Line
Human HEK293H cells
Sequence
LRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSG
Host
Human
Theoretical MW (kDa)
34.21
Interspecies Antigen Sequence
Mouse (61); Rat (61)
Form
Liquid
Preparation Method
Transfection of pSuper-PLAUR plasmid into HEK293H cell, and the expressed protein was purified by Strep-Tactin affinity column.
Purification
Strep-Tactin affinity columns
Concentration
≥ 10 ug/ml
Quality Control Testing
Western Blot
Western Blot
Storage Buffer
100 mM Tris-HCl pH 8.0, 150 mM NaCl, 1 mM EDTA, and 5 mM desthiobiotin.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
SDS-PAGE
Protein Interaction
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Gene Info — PLAUR
Entrez GeneID
5329GeneBank Accession#
NM_002659.2Protein Accession#
NP_002650.1Gene Name
PLAUR
Gene Alias
CD87, UPAR, URKR
Gene Description
plasminogen activator, urokinase receptor
Omim ID
173391Gene Ontology
HyperlinkGene Summary
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq
Other Designations
monocyte activation antigen Mo3|u-plasminogen activator receptor form 2
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Interactomes
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Pathways
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Diseases
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