PLAUR (Human) Recombinant Protein
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More Files
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Enzyme-linked Immunoabsorbent Assay
Immobilized Human PLAU, His Tag at 0.5 ug/mL (100 uL/Well) on the plate. Dose response curve for Human uPAR, hFc Tag with the EC50 of 2.4 ng/mL determined by ELISA.
SEC-HPLC
The purity of Human uPAR is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human uPAR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
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Specification
Product Description
Human PLAUR (Q03405-1, Leu23-Gly305) partial recombinant protein with hFc tag at C-Terminus expressed in HEK293 cells.
Sequence
Leu23-Gly305
Host
Human
Theoretical MW (kDa)
58.2
Form
Liquid
Preparation Method
Mammalian cell (HEK293) expression system
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human uPAR is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human uPAR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS pH 7.4
Storage Instruction
Store at -80°C for 12 Month.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Human PLAU, His Tag at 0.5 ug/mL (100 uL/Well) on the plate. Dose response curve for Human uPAR, hFc Tag with the EC50 of 2.4 ng/mL determined by ELISA.Functional Study
SDS-PAGE
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Gene Info — PLAUR
Entrez GeneID
5329Protein Accession#
Q03405-1Gene Name
PLAUR
Gene Alias
CD87, UPAR, URKR
Gene Description
plasminogen activator, urokinase receptor
Omim ID
173391Gene Ontology
HyperlinkGene Summary
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq
Other Designations
monocyte activation antigen Mo3|u-plasminogen activator receptor form 2
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Interactome
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Pathway
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Disease
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