ORC2L monoclonal antibody (M01), clone 3E11-1G5
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More Files
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Western Blot (Cell lysate)
ORC2L monoclonal antibody (M01), clone 3E11-1G5. Western Blot analysis of ORC2L expression in Hela S3 NE ( Cat # L013V3 ).
Western Blot (Cell lysate)
ORC2L monoclonal antibody (M01), clone 3E11-1G5 Western Blot analysis of ORC2L expression in Jurkat ( Cat # L017V1 ).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to ORC2L on formalin-fixed paraffin-embedded human spleen tissue.[antibody concentration 5 ug/ml]
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged ORC2L is approximately 0.3ng/ml as a capture antibody.
Western Blot detection against Immunogen (89.21 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant ORC2L.
Immunogen
ORC2L (AAH14834, 1 a.a. ~ 577 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MSKPELKEDKMLEVHFVGDDDVLNHILDREGGAKLKKERAQLLVNPKKIIKKPEYDLEEDDQEVLKDQNYVEIMGRDVQESLKNGSATGGGNKVYSFQNRKHSEKMAKLASELAKTPQKSVSFSLKNDPEITINVPQSSKGHSASDKVQPKNNDKSEFLSTAPRSLRKRLIVPRSHSDSESEYSASNSEDDEGVAQEHEEDTNAVIFSQKIQAQNRVVSAPVGKETPSKRMKRDKTSDLVEEYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVSPSFSAELKQLNQQYEKLFHKWMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVINGFFPGISVKSVLNSITEEVLDHMGTFRSILDQLDWIVNKFKEDSSLELFLLIHNLDSQMLRGEKSQQIIGQLSSLHNIYLIASIDHLNAPLMWDHAKQSLFNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLTHVLRSLTPNARGIFRLLIKYQLDNQDNPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDNGTLTDFLEKEEEEA
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (79); Rat (79)
Isotype
IgG1 kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (89.21 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
ORC2L monoclonal antibody (M01), clone 3E11-1G5. Western Blot analysis of ORC2L expression in Hela S3 NE ( Cat # L013V3 ).Western Blot (Cell lysate)
ORC2L monoclonal antibody (M01), clone 3E11-1G5 Western Blot analysis of ORC2L expression in Jurkat ( Cat # L017V1 ).Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to ORC2L on formalin-fixed paraffin-embedded human spleen tissue.[antibody concentration 5 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged ORC2L is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — ORC2L
Entrez GeneID
4999GeneBank Accession#
BC014834Protein Accession#
AAH14834Gene Name
ORC2L
Gene Alias
ORC2
Gene Description
origin recognition complex, subunit 2-like (yeast)
Omim ID
601182Gene Ontology
HyperlinkGene Summary
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3L, -4L, and -5L. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. [provided by RefSeq
Other Designations
origin of replication 2-like|origin recognition complex protein 2 homolog|origin recognition complex, subunit 2
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Interactome
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Pathway
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Publication Reference
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RBM3-regulated genes promote DNA integrity and affect clinical outcome in epithelial ovarian cancer.
Ehlen A, Nodin B, Rexhepaj E, Brandstedt J, Uhlen M, Alvarado-Kristensson M, Ponten F, Brennan DJ, Jirstrom K.
Translational Oncology 2011 Aug; 4(4):212.
Application：WB-Ce, Human, A2780 Cells.
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RBM3-regulated genes promote DNA integrity and affect clinical outcome in epithelial ovarian cancer.
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