Products

Western Blot (Recombinant protein)

ELISA

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

NPR2

Gene Alias

AMDM, ANPRB, GUC2B, GUCY2B, NPRB, NPRBi

Gene Description

natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)

Omim ID

Gene Ontology

Gene Summary

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq

Other Designations

OTTHUMP00000021345|OTTHUMP00000045390|atrial natriuretic peptide B-type receptor|guanylate cyclase B|natriuretic peptide receptor B