Products

Immunoprecipitation

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

IDH2

Gene Alias

ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH

Gene Description

isocitrate dehydrogenase 2 (NADP+), mitochondrial

Omim ID

Gene Ontology

Gene Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. [provided by RefSeq

Other Designations

NADP+-specific ICDH|isocitrate dehydrogenase, mitochondrial|oxalosuccinate decarboxylase