GCLM monoclonal antibody (M02), clone 2C6
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant GCLM.
Immunogen
GCLM (AAH41809, 1 a.a. ~ 274 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINPDLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSGASFQEALQESIPDIQAHEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS
Host
Mouse
Reactivity
Human, Rat
Isotype
IgG2a Lambda
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (55.88 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
GCLM monoclonal antibody (M02), clone 2C6. Western Blot analysis of GCLM expression in PC-12 ( Cat # L012V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — GCLM
Entrez GeneID
2730GeneBank Accession#
BC041809Protein Accession#
AAH41809Gene Name
GCLM
Gene Alias
GLCLR
Gene Description
glutamate-cysteine ligase, modifier subunit
Omim ID
601176Gene Ontology
HyperlinkGene Summary
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq
Other Designations
GSC light chain|OTTHUMP00000012299|gamma-glutamylcysteine synthetase|glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)|glutamate-cysteine ligase regulatory protein
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Interactome
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Pathway
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Disease
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