Immunoprecipitation of GCLM transfected lysate using anti-GCLM MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with GCLM purified MaxPab mouse polyclonal antibody (B01P) (H00002730-B01P).
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq