Immunoprecipitation of GLA transfected lysate using anti-GLA MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with GLA purified MaxPab mouse polyclonal antibody (B01P) (H00002717-B01P).
This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq