GCK MaxPab mouse polyclonal antibody (B01)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human GCK protein.
Immunogen
GCK (NP_000153, 1 a.a. ~ 465 a.a) full-length human protein.
Sequence
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Rat (95)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Note
For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
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Applications
Western Blot (Tissue lysate)
GCK MaxPab polyclonal antibody. Western Blot analysis of GCK expression in human liver.Western Blot (Tissue lysate)
GCK MaxPab polyclonal antibody. Western Blot analysis of GCK expression in human pancreas.Western Blot (Transfected lysate)
Western Blot analysis of GCK expression in transfected 293T cell line (H00002645-T01) by GCK MaxPab polyclonal antibody.
Lane 1: GCK transfected lysate(51.15 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — GCK
Entrez GeneID
2645GeneBank Accession#
NM_000162Protein Accession#
NP_000153Gene Name
GCK
Gene Alias
GK, GLK, HHF3, HK4, HKIV, HXKP, MODY2
Gene Description
glucokinase (hexokinase 4)
Gene Ontology
HyperlinkGene Summary
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq
Other Designations
ATP:D-hexose 6-phosphotransferase|OTTHUMP00000024521|OTTHUMP00000159308|glucokinase|hexokinase D, pancreatic isozyme
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Interactome
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Pathway
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Disease
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Publication Reference
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Ascorbylperoxide contaminating parenteral nutrition perturbs the lipid metabolism in newborn guinea pig.
Maghdessian R, Côté F, Rouleau T, Ben Djoudi Ouadda A, Levy E, Lavoie JC.
The Journal of Pharmacology and Experimental Therapeutics 2010 Jul; 334(1):278.
Application:WB-Ti, Mouse, Mouse livers.
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Ascorbylperoxide contaminating parenteral nutrition perturbs the lipid metabolism in newborn guinea pig.
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