GAS6 (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human GAS6 full-length ORF ( NP_000811.1, 1 a.a. - 678 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
101.3
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — GAS6
Entrez GeneID
2621GeneBank Accession#
NM_000820.1Protein Accession#
NP_000811.1Gene Name
GAS6
Gene Alias
AXLLG, AXSF, DKFZp666G247, FLJ34709
Gene Description
growth arrest-specific 6
Omim ID
600441Gene Ontology
HyperlinkGene Summary
This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
AXL receptor tyrosine kinase ligand|AXL stimulatory factor|OTTHUMP00000018777
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Interactome
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Disease
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Publication Reference
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Gas6 Promotes Microglia Efferocytosis and Suppresses Inflammation Through Activating Axl/Rac1 Signaling in Subarachnoid Hemorrhage Mice.
Junjia Tang, Yichao Jin, Feng Jia, Tao Lv, Anatol Manaenko, Lin-Feng Zhang, Zeyu Zhang, Xin Qi, Yajun Xue, Bin Zhao, Xiaohua Zhang, John H Zhang, Jianfei Lu, Qin Hu.
Translational Stroke Research 2022 Nov; [Epub].
Application：Sub, Mouse, Mouse brain cortex.
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Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.
Fujita K, Chen X, Homma H, Tagawa K, Amano M, Saito A, Imoto S, Akatsu H, Hashizume Y, Kaibuchi K, Miyano S, Okazawa H.
Nature Communications 2018 Jan; 9(1):433.
Application：PI, WB-Re, Recombinant protein.
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Gas6 Promotes Microglia Efferocytosis and Suppresses Inflammation Through Activating Axl/Rac1 Signaling in Subarachnoid Hemorrhage Mice.
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