F2R monoclonal antibody (M01), clone 2C5
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant F2R.
Immunogen
F2R (NP_001983.1, 42 a.a. ~ 102 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
SFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLT
Host
Mouse
Reactivity
Human
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (32.45 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged F2R is 0.1 ng/ml as a capture antibody.ELISA
In situ Proximity Ligation Assay (Cell)
Proximity Ligation Analysis of protein-protein interactions between MMP1 and F2R. HeLa cells were stained with anti-MMP1 rabbit purified polyclonal 1:1200 and anti-F2R mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue). -
Gene Info — F2R
Entrez GeneID
2149GeneBank Accession#
NM_001992Protein Accession#
NP_001983.1Gene Name
F2R
Gene Alias
CF2R, HTR, PAR1, TR
Gene Description
coagulation factor II (thrombin) receptor
Omim ID
187930Gene Ontology
HyperlinkGene Summary
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq
Other Designations
coagulation factor II receptor|protease-activated receptor 1|thrombin receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Altered Protease-Activated Receptor-1 Expression and Signaling in a Malignant Pleural Mesothelioma Cell Line, NCI-H28, with Homozygous Deletion of the β-Catenin Gene.
Fazzini A.
PLoS One 2014 Nov; 9(11):e111550.
Application:IF, WB-Ce, Human, Primary mesothelial cells, Met-5A, NCI-H28, REN, Ist-Mes2, Mero-14 cells.
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Altered Protease-Activated Receptor-1 Expression and Signaling in a Malignant Pleural Mesothelioma Cell Line, NCI-H28, with Homozygous Deletion of the β-Catenin Gene.
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