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Last updated: 2016/10/23
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DFFB purified MaxPab rabbit polyclonal antibody (D01P)MaxPab

  • Catalog # : H00001677-D01P
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against a full-length human DFFB protein.
  • Immunogen:
  • DFFB (NP_004393.1, 1 a.a. ~ 338 a.a) full-length human protein.
  • Sequence:
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Quality Control Testing:
  • Antibody reactive against mammalian transfected lysate.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • DFFB MaxPab rabbit polyclonal antibody. Western Blot analysis of DFFB expression in mouse liver.
  • PDF DownloadProtocol Download
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western Blot analysis of DFFB expression in transfected 293T cell line (H00001677-T02) by DFFB MaxPab polyclonal antibody.

    Lane 1: DFFB transfected lysate(39.10 KDa).
    Lane 2: Non-transfected lysate.
  • PDF DownloadProtocol Download
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 1677
  • Gene Name:
  • DFFB
  • Gene Alias:
  • Gene Description:
  • DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
  • Gene Summary:
  • Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq
  • Other Designations:
  • DNA fragmentation factor, 40 kD, beta polypeptide,DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase),DNA fragmentation factor, 40 kD, beta subunit,OTTHUMP00000003633,caspase-activated deoxyribonuclease,caspase-activated nuclease
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