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CISH mouse monoclonal antibody (hybridoma)

  • Catalog # : H00001154-M
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against a full-length recombinant CISH.
  • Immunogen:
  • CISH (NP_659508.1, 1 a.a. ~ 258 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
  • Sequence:
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Antibody reactivity and specificity confirmed by ELISA and Western Blot.
  • Note:
  • Customer should check the viability of the hybridomas within one month from the date of receipt. Fee-for-service of long term hybridoma storage can be performed upon customer's request.
  • Deliverables:
  • Up to 5 positive hybridoma clones will be delivered to customer in the cryotube format.
  • Applications
  • Application Image
  • Western Blot (Transfected lysate)
  • Western Blot (Recombinant protein)
  • Gene Information
  • Entrez GeneID:
  • 1154
  • Gene Name:
  • CISH
  • Gene Alias:
  • CIS,CIS-1,G18,SOCS
  • Gene Description:
  • cytokine inducible SH2-containing protein
  • Gene Summary:
  • The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • cytokine-inducible SH2-containing protein,cytokine-inducible inhibitor of signaling type 1B,suppressor of cytokine signaling
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