DST monoclonal antibody (M01), clone 1B10
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More Files
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Specifications
Product Description
Mouse monoclonal antibody raised against a partial recombinant DST.
Immunogen
DST (NP_899236, 401 a.a. ~ 500 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
EDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMIS
Host
Mouse
Reactivity
Human
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged DST is approximately 0.1ng/ml as a capture antibody.ELISA
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Gene Info — DST
Entrez GeneID
667GeneBank Accession#
NM_183380Protein Accession#
NP_899236Gene Name
DST
Gene Alias
BP240, BPA, BPAG1, CATX-15, D6S1101, DKFZp564B2416, DMH, DT, FLJ46791, KIAA0465, KIAA1470, MACF2
Gene Description
dystonin
Omim ID
113810Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been known that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq
Other Designations
OTTHUMP00000016657|OTTHUMP00000040015|bullous pemphigoid antigen 1, 230/240kDa|dystonia musculorum of mouse, human homolog of|hemidesmosomal plaque protein
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Interactomes
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Diseases
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Publication Reference
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Dystonin/Bpag1 is a necessary endoplasmic reticulum/nuclear envelope protein in sensory neurons.
Young KG, Kothary R.
Experimental Cell Research 2008 Jul; 314(15):2750.
Application:IF, Mouse, Mouse dorsal root ganglia.
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Dystonin/Bpag1 is a necessary endoplasmic reticulum/nuclear envelope protein in sensory neurons.
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