BRAF/LMO7 Translocation FISH Probe
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Specification
Product Description
Labeled FISH probes for identification of gene translocation using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: BRAF
Size: Approximately 1050kb
Fluorophore: FITC
Location: 7q34Probe 2
Name: LMO7
Size: Approximately 870kb
Fluorophore: Texas Red
Location: 13q22.2Origin
Human
Source
Genomic DNA
Reactivity
Human
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulatory Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome.
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Applications
Fluorescent In Situ Hybridization (Cell)
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Gene Info — BRAF
Entrez GeneID
673Gene Name
BRAF
Gene Alias
B-RAF1, BRAF1, FLJ95109, MGC126806, MGC138284, RAFB1
Gene Description
v-raf murine sarcoma viral oncogene homolog B1
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq
Other Designations
94 kDa B-raf protein|B-Raf proto-oncogene serine/threonine-protein kinase (p94)|Murine sarcoma viral (v-raf) oncogene homolog B1
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Gene Info — LMO7
Entrez GeneID
4008Gene Name
LMO7
Gene Alias
FBX20, FBXO20, KIAA0858, LOMP
Gene Description
LIM domain 7
Omim ID
604362Gene Ontology
HyperlinkGene Summary
This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq
Other Designations
F-box only protein 20|F-box protein Fbx20|LIM domain only 7|OTTHUMP00000018512|OTTHUMP00000040819|zinc-finger domain-containing protein
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Interactome
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Pathway
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Disease
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