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EGFR/MET/CEN7q FISH Probe

  • Catalog # : FG0205
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
  • Quality Control Testing:
  • Representative images of normal human cell (lymphocyte) stain with the triple color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.

    QC Testing of FG0205
  • Supplied Product:
  • DAPI Counterstain (1500 ng/mL ) 250 uL
  • Storage Instruction:
  • Store at 4°C in the dark.
  • Note:
  • Hybridization position of the probes on the chromosome.

  • Probe 2:
        Size:
        Fluorophore:
        Location:
  • MET(c-met)
    Approximately 270kb
    TexRed
    7q31
  • Probe 1:
        Size:
        Fluorophore:
        Location:
  • EGFR
    Approximately 320kb
    R6G
    7q12
  • Probe 3:
        Size:
        Fluorophore:
        Location:
  • CEN7q
    Approximately 800kb
    FITC
    7q11.21
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Notice:
  • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Application Image
  • Fluorescent In Situ Hybridization (Cell)
  • Gene Information
  • Entrez GeneID:
  • 1956
  • Gene Name:
  • EGFR
  • Gene Alias:
  • ERBB,ERBB1,HER1,PIG61,mENA
  • Gene Description:
  • epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
  • Gene Summary:
  • The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq
  • Other Designations:
  • avian erythroblastic leukemia viral (v-erb-b) oncogene homolog,cell growth inhibiting protein 40,cell proliferation-inducing protein 61,epidermal growth factor receptor
  • Gene Information
  • Entrez GeneID:
  • 4233
  • Gene Name:
  • MET
  • Gene Alias:
  • AUTS9,HGFR,RCCP2,c-Met
  • Gene Description:
  • met proto-oncogene (hepatocyte growth factor receptor)
  • Gene Summary:
  • The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • HGF receptor,OTTHUMP00000069168,SF receptor,met proto-oncogene,met proto-oncogene tyrosine kinase,oncogene MET,scatter factor receptor
  • Interactome 1
  • Interactome
  • Interactome 2
  • Interactome
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