FGF19/CEN11p FISH Probe
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More Files
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human breast (FFPE) stained with FGF19/CEN11p FISH Probe. Human breast showed no FGF19 amplification.
Hybridization position of the probes on the chromosome.
Hybridization position of the probes on the chromosome.
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Specification
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: FGF19
Size: Approximately 170kb
Fluorophore: Texas Red
Location: 11q13.1Probe 2
Name: CEN11p
Size: Approximately 630kb
Fluorophore: FITC
Location: 11p11.12Probe Gap
The gap between two probes is approximately 21,900 kb
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome.
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Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human breast (FFPE) stained with FGF19/CEN11p FISH Probe. Human breast showed no FGF19 amplification. -
Gene Info — FGF19
Entrez GeneID
9965Gene Name
FGF19
Gene Alias
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Gene Description
fibroblast growth factor 19
Omim ID
603891Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Publication Reference
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FGF19 genetic amplification as a potential therapeutic target in lung squamous cell carcinomas.
Zhang X, Kong M, Zhang Z, Xu S, Yan F, Wei L, Zhou J.
Thoracic Cancer 2017 Sep; 8(6):655.
Application：FISH, Human, Human lung squamous cell carcinoma.
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FGF19 genetic amplification as a potential therapeutic target in lung squamous cell carcinomas.
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