TNFAIP3/CEN6p FISH Probe
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Specification
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: TNFAIP3
Size: Approximately 260kb
Fluorophore: Texas Red
Location: 6q23Probe 2
Name: CEN6p
Size: Approximately 660kb
Fluorophore: FITC
Location: 6p12.1Probe Gap
The gap between two probes is approximately 83,100 kb
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome.
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Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human colon cancer (FFPE) stained with TNFAIP3/CEN6p FISH Probe. Human colon cancer showed no TNFAIP3 amplification. -
Gene Info — TNFAIP3
Entrez GeneID
7128Gene Name
TNFAIP3
Gene Alias
A20, MGC104522, MGC138687, MGC138688, OTUD7C, TNFA1P2
Gene Description
tumor necrosis factor, alpha-induced protein 3
Omim ID
191163Gene Ontology
HyperlinkGene Summary
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses. [provided by RefSeq
Other Designations
OTTHUMP00000017289|tumor necrosis factor inducible protein A20
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