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Last updated: 2016/12/4

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TOP1/CEN20p FISH Probe

  • Catalog # : FG0094
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  • Specification
  • Product Description:
  • Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
  • Form:
  • Liquid
  • Quality Control Testing:
  • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.

    QC Testing of FG0094
  • Supplied Product:
  • DAPI Counterstain (1500 ng/mL ) 250 uL
  • Storage Instruction:
  • Store at 4°C in the dark.
  • Probe 1:
        Size:
        Fluorophore:
        Location:
  • TOP1
    Approximately 420kb
    TexRed
    20q12
  • Probe 2:
        Size:
        Fluorophore:
        Location:
  • CEN20p
    Approximately 400kb
    FITC
    20p11.21
  • Probe Gap:
  • The gap between two probes is approximately 17100 kb.
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Notice:
  • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections) enlargeenlarge this image
  • Human colon cancer (FFPE) stained with TOP1/CEN20p FISH Probe. Human colon cancer showed no TOP1 gene split.
  • PDF DownloadProtocol Download
  • Application Image
  • Fluorescent In Situ Hybridization (Cell)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 7150
  • Gene Name:
  • TOP1
  • Gene Alias:
  • TOPI
  • Gene Description:
  • topoisomerase (DNA) I
  • Gene Summary:
  • This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq
  • Other Designations:
  • DNA topoisomerase I,OTTHUMP00000031713,type I DNA topoisomerase
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