SLC31A/CEN9q FISH Probe
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More Files
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Huma lung, adenosquamous cell carcinoma (FFPE) stained with SLC31A/CEN9q FISH Probe. Human lung, adenosquamous cell carcinoma showed SLC31A gene amplification.
Hybridization position of the probes on the chromosome:
Hybridization position of the probes on the chromosome:
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Specification
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: SLC31A
Size: Approximately 300kb
Fluorophore: Texas Red
Location: 9q32Probe 2
Name: CEN9q
Size: Approximately 470kb
Fluorophore: FITC
Location: 9q21Probe Gap
The gap between two probes is approximately 44,000 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome:
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Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Huma lung, adenosquamous cell carcinoma (FFPE) stained with SLC31A/CEN9q FISH Probe. Human lung, adenosquamous cell carcinoma showed SLC31A gene amplification. -
Gene Info — SLC31A1
Entrez GeneID
1317Gene Name
SLC31A1
Gene Alias
COPT1, CTR1, MGC75487, hCTR1
Gene Description
solute carrier family 31 (copper transporters), member 1
Omim ID
603085Gene Ontology
HyperlinkGene Summary
Copper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, and intracellular compartmentalization or buffering of copper strictly regulated. The 2 related genes ATP7A (MIM 300011) and ATP7B (MIM 606882), responsible for the human diseases Menkes syndrome (MIM 309400) and Wilson disease (MIM 277900), respectively, are involved in copper export. In S. cerevisiae, the copper uptake genes CTR1, CTR2, and CTR3 have been identified, and in human the CTR1 and CTR2 (MIM 603088) genes have been identified.[supplied by OMIM
Other Designations
OTTHUMP00000021950|copper transport 1 homolog|copper transporter 1
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