ATP7B/CEN13q FISH Probe
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human stomach carcinoma (FFPE) stained with ATP7B/CEN13q FISH Probe. Human stomach carcinoma showed no ATP7B gene amplification.
Hybridization position of the probes on the chromosome:
Hybridization position of the probes on the chromosome:
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Specification
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: ATP7B
Size: Approximately 350kb
Fluorophore: Texas Red
Location: 13q14.3Probe 2
Name: CEN13q
Size: Approximately 550kb
Fluorophore: FITC
Location: 13q12.11Probe Gap
The gap between two probes is approximately 24,100 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome:
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Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human stomach carcinoma (FFPE) stained with ATP7B/CEN13q FISH Probe. Human stomach carcinoma showed no ATP7B gene amplification. -
Gene Info — ATP7B
Entrez GeneID
540Gene Name
ATP7B
Gene Alias
PWD, WC1, WD, WND
Gene Description
ATPase, Cu++ transporting, beta polypeptide
Gene Ontology
HyperlinkGene Summary
This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq
Other Designations
ATPase, Cu(2+)- transporting, beta polypeptide|OTTHUMP00000040880|Wilson disease-associated protein|copper pump 2|copper-transporting ATPase 2
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Interactome
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Disease
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