ATOX1/CEN5q FISH Probe
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human breast cancer (FFPE) stained with ATOX1/CEN5q FISH Probe. Human breast cancer showed no ATOX1 gene amplification
Hybridization position of the probes on the chromosome:
Hybridization position of the probes on the chromosome:
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Specifications
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: ATOX1
Size: Approximately 250kb
Fluorophore: Texas Red
Location: 5q32Probe 2
Name: CEN5q
Size: Approximately 700kb
Fluorophore: FITC
Location: 5q11.2Probe Gap
The gap between two probes is approximately 98,300 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome:
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Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human breast cancer (FFPE) stained with ATOX1/CEN5q FISH Probe. Human breast cancer showed no ATOX1 gene amplification -
Gene Info — ATOX1
Entrez GeneID
475Gene Name
ATOX1
Gene Alias
ATX1, HAH1, MGC138453, MGC138455
Gene Description
ATX1 antioxidant protein 1 homolog (yeast)
Omim ID
602270Gene Ontology
HyperlinkGene Summary
This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq
Other Designations
antioxidant protein 1|copper transport protein|metal transport protein
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