TRF1/CEN8p FISH Probe
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human hepatocellular carcinoma (FFPE) stained with TRF1/CEN8p FISH Probe. Human hepatocellular carcinoma showed no TRF1 gene amplification.
Hybridization position of the probes on the chromosome.
Hybridization position of the probes on the chromosome.
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Specification
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: TRF1
Size: Approximately 290kb
Fluorophore: Texas Red
Location: 8q13Probe 2
Name: CEN8p
Size: Approximately 520kb
Fluorophore: FITC
Location: 8p11.21Probe Gap
The gap between two probes is approximately 33,200 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome. -
Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human hepatocellular carcinoma (FFPE) stained with TRF1/CEN8p FISH Probe. Human hepatocellular carcinoma showed no TRF1 gene amplification. -
Gene Info — TERF1
Entrez GeneID
7013Gene Name
TERF1
Gene Alias
FLJ41416, PIN2, TRBF1, TRF, TRF1, hTRF1-AS, t-TRF1
Gene Description
telomeric repeat binding factor (NIMA-interacting) 1
Omim ID
600951Gene Ontology
HyperlinkGene Summary
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq
Other Designations
telomeric repeat binding factor 1|telomeric repeat binding protein 1
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Interactome
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Disease
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