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Last updated: 2017/12/10

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HER4/CEN2p FISH Probe

  • Catalog # : FG0024
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
  • Quality Control Testing:
  • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.

    QC Testing of FG0024
  • Supplied Product:
  • DAPI Counterstain (1500 ng/mL ) 250 uL
  • Storage Instruction:
  • Store at 4°C in the dark.
  • Note:

  • Hybridization position of the probes on the chromosome.

  • Probe 1:
        Size:
        Fluorophore:
        Location:
  • HER4
    Approximately 360kb
    Texas Red
    2q33-q34
  • Probe 2:
        Size:
        Fluorophore:
        Location:
  • CEN2p
    Approximately 670kb
    FITC
    2p11.2
  • Probe Gap:
  • The gap between two probes is approximately 126,300 kb.
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Notice:
  • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections) enlargeenlarge this image
  • Human breast cancer (FFPE) stained with HER4/CEN2p FISH Probe. Human breast cancer showed no HER4 gene amplification.
  • PDF DownloadProtocol Download
  • Application Image
  • Fluorescent In Situ Hybridization (Cell)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 2066
  • Gene Name:
  • ERBB4
  • Gene Alias:
  • HER4,MGC138404,p180erbB4
  • Gene Description:
  • v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
  • Gene Summary:
  • This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq
  • Other Designations:
  • avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4,receptor tyrosine-protein kinase erbB-4,tyrosine kinase-type cell surface receptor HER4,v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4,v-erb-a erythroblastic leukemia v
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