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Fluorescent In Situ Hybridization (Cell)

Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)

Human breast cancer (FFPE) stained with HER4/CEN2p FISH Probe. Human breast cancer showed no HER4 gene amplification.

Entrez GeneID

2066

Gene Name

ERBB4

Gene Alias

HER4, MGC138404, p180erbB4

Gene Description

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

Omim ID

600543

Gene Ontology

Hyperlink

Gene Summary

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq

Other Designations

avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4|receptor tyrosine-protein kinase erbB-4|tyrosine kinase-type cell surface receptor HER4|v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4|v-erb-a erythroblastic leukemia v