Products

Fluorescent In Situ Hybridization (Cell)

Entrez GeneID

Gene Name

TCEB2

Gene Alias

ELOB, SIII

Gene Description

transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)

Omim ID

Gene Ontology

Gene Summary

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq

Other Designations

RNA polymerase II transcription factor SIII p18 subunit|SIII p18|elongin B|elongin, 18-kD subunit|transcription elongation factor B (SIII), polypeptide 2 (18kD, elongin B)