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Last updated: 2017/7/23

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HLA-C FISH Probe

  • Catalog # : FA0164
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  • Specification
  • Product Description:
  • Made to order FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology)
  • Supplied Product:
  • DAPI Counterstain (1500 ng/mL ) 250 uL
  • Storage Instruction:
  • Store at 4°C in the dark.
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Notice:
  • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Application Image
  • Fluorescent In Situ Hybridization (Cell)
  • Gene Information
  • Entrez GeneID:
  • 3107
  • Gene Name:
  • HLA-C
  • Gene Alias:
  • D6S204,FLJ27082,HLA-Cw,HLA-Cw12,HLA-JY3,HLC-C,PSORS1
  • Gene Description:
  • major histocompatibility complex, class I, C
  • Gene Summary:
  • HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq
  • Other Designations:
  • HLA class I antigen,HLA class I heavy chain,HLA class I histocompatibility antigen, C alpha chain,HLA-C (Cw*1201),HLA-Cw*050x,MHC class I HLA-C,MHC class I HLA-Cw*0803,MHC class I antigen HLA-C,MHC class I antigen heavy chain HLA-C,MHC class I protein HLA
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