Products

In situ Proximity Ligation Assay (Cell)

Entrez GeneID

Gene Name

PTK2

Gene Alias

FADK, FAK, FAK1, pp125FAK

Gene Description

PTK2 protein tyrosine kinase 2

Omim ID

Gene Ontology

Gene Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined. [provided by RefSeq

Other Designations

focal adhesion kinase 1

Entrez GeneID

Gene Name

SRC

Gene Alias

ASV, SRC1, c-SRC, p60-Src

Gene Description

v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)

Omim ID

Gene Ontology

Gene Summary

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq

Other Designations

OTTHUMP00000174476|OTTHUMP00000174477|proto-oncogene tyrosine-protein kinase SRC|protooncogene SRC, Rous sarcoma|tyrosine kinase pp60c-src|tyrosine-protein kinase SRC-1