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Last updated: 2016/12/4
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IGF1R & MDM2 Protein Protein Interaction Antibody Pair

  • Catalog # : DI0323
  • Visit Frequency :
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  • Specification
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Protein protein interaction immunofluorescence result.

    QC Testing of DI0323
    Representative image of Proximity Ligation Assay of protein-protein interactions between IGF1R and MDM2. HeLa cells were stained with anti-IGF1R rabbit purified polyclonal antibody 1:1200 and anti-MDM2 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
  • Supplied Product:
  • Antibody pair set content:
    1. IGF1R rabbit purified polyclonal antibody (20 ug)
    2. MDM2 mouse monoclonal antibody (40 ug)
    *Reagents are sufficient for at least 30-50 assays using recommended protocols.
  • Storage Instruction:
  • Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
  • Publication Reference
  • Applications
  • In situ Proximity Ligation Assay (Cell)
  • Application Image
  • In situ Proximity Ligation Assay (Cell)
  • Gene Information
  • Entrez GeneID:
  • 3480
  • Gene Name:
  • IGF1R
  • Gene Alias:
  • CD221,IGFIR,JTK13,MGC142170,MGC142172,MGC18216
  • Gene Description:
  • insulin-like growth factor 1 receptor
  • Gene Summary:
  • This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq
  • Other Designations:
  • soluble IGF1R variant 1,soluble IGF1R variant 2
  • Gene Information
  • Entrez GeneID:
  • 4193
  • Gene Name:
  • MDM2
  • Gene Alias:
  • HDMX,MGC71221,hdm2
  • Gene Description:
  • Mdm2 p53 binding protein homolog (mouse)
  • Gene Summary:
  • This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq
  • Other Designations:
  • Mdm2, transformed 3T3 cell double minute 2, p53 binding protein,double minute 2, human homolog of; p53-binding protein,mouse double minute 2 homolog,p53-binding protein MDM2,ubiquitin-protein ligase E3 Mdm2
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