IGF1R & PIK3R3 Protein Protein Interaction Antibody Pair
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Specification
Product Description
This protein protein interaction antibody pair set comes with two antibodies to detect the protein-protein interaction, one against the IGF1R protein, and the other against the PIK3R3 protein for use in in situ Proximity Ligation Assay. See Publication Reference below.
Reactivity
Human
Quality Control Testing
Protein protein interaction immunofluorescence result.
Representative image of Proximity Ligation Assay of protein-protein interactions between IGF1R and PIK3R3. HeLa cells were stained with anti-IGF1R rabbit purified polyclonal antibody 1:1200 and anti-PIK3R3 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
Supplied Product
Antibody pair set content:
1. IGF1R rabbit purified polyclonal antibody (100 ug)
2. PIK3R3 mouse monoclonal antibody (40 ug)
*Reagents are sufficient for at least 30-50 assays using recommended protocols.Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
In situ Proximity Ligation Assay (Cell)
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Gene Info — IGF1R
Entrez GeneID
3480Gene Name
IGF1R
Gene Alias
CD221, IGFIR, JTK13, MGC142170, MGC142172, MGC18216
Gene Description
insulin-like growth factor 1 receptor
Omim ID
147370Gene Ontology
HyperlinkGene Summary
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq
Other Designations
soluble IGF1R variant 1|soluble IGF1R variant 2
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Gene Info — PIK3R3
Entrez GeneID
8503Gene Name
PIK3R3
Gene Alias
DKFZp686P05226, FLJ41892, p55, p55-GAMMA
Gene Description
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Omim ID
606076Gene Ontology
HyperlinkGene Summary
O
Other Designations
100% homology to SWISS-PROT Q92569|OTTHUMP00000009783|OTTHUMP00000009786|phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)|phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)|phosphoinositide-3-kinase, regulatory subun
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Interactome
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Disease
- Abortion
- Adenocarcinoma
- Adenoma
- Alzheimer disease
- Anemia
- Aneuploidy
- Atherosclerosis
- Bacteremia
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