DUSP6 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
The DUSP6 polyclonal antibody (Cat # PAB4131) is used in Western blot to detect DUSP6 in HeLa cell lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DUSP6.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human DUSP6.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The DUSP6 polyclonal antibody (Cat # PAB4131) is used in Western blot to detect DUSP6 in HeLa cell lysate.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DUSP6
Entrez GeneID
1848Protein Accession#
NP_073143;NP_001937Gene Name
DUSP6
Gene Alias
MKP3, PYST1
Gene Description
dual specificity phosphatase 6
Omim ID
602748Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
MAP kinase phosphatase 3|serine/threonine specific protein phosphatase
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Interactome
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Pathway
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Disease
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Publication Reference
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Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas.
Furukawa T, Fujisaki R, Yoshida Y, Kanai N, Sunamura M, Abe T, Takeda K, Matsuno S, Horii A.
Modern Pathology 2005 Aug; 18(8):1034.
Application：IHC-P, Human, Human pancreatic tissues.
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Abrogation of DUSP6 by hypermethylation in human pancreatic cancer.
Xu S, Furukawa T, Kanai N, Sunamura M, Horii A.
Journal of Human Genetics 2005 Apr; 50(4):159.
Application：IHC-P, Human, Human pancreatic tissues with invasive ductal carcinoma.
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Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal.
Karlsson M, Mathers J, Dickinson RJ, Mandl M, Keyse SM.
The Journal of Biological Chemistry 2004 Jul; 279(40):41882.
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Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas.
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