Products

Western Blot (Cell lysate)

The GUCA1A polyclonal antibody (Cat # PAB3612) is used in Western blot to detect GUCA1A in Y-79 cell lysate.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with GUCA1A polyclonal antibody (Cat # PAB3612) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.

Entrez GeneID

2978

Protein Accession#

P43080

Gene Name

GUCA1A

Gene Alias

COD3, GCAP, GCAP1, GUCA, GUCA1

Gene Description

guanylate cyclase activator 1A (retina)

Omim ID

600364 602093

Gene Ontology

Hyperlink

Gene Summary

This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. [provided by RefSeq

Other Designations

OTTHUMP00000016397|OTTHUMP00000196466