IRAK1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IRAK1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human IRAK1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of IRAK1 polyclonal antibody (Cat # PAB3469) in Jurkat cell lysate. IRAK1 (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with IRAK1 polyclonal antibody (Cat # PAB3469) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. -
Gene Info — IRAK1
Entrez GeneID
3654Protein Accession#
P51617Gene Name
IRAK1
Gene Alias
IRAK, pelle
Gene Description
interleukin-1 receptor-associated kinase 1
Omim ID
300283Gene Ontology
HyperlinkGene Summary
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000026014|OTTHUMP00000026020|Pelle homolog
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Interactome
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Pathway
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Disease
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Publication Reference
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Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein.
Jensen LE, Whitehead AS.
The Journal of Immunology 2003 Aug; 171(3):1500.
Application:IP, WB-Tr, Human, 293 cells.
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Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.
Jiang Z, Johnson HJ, Nie H, Qin J, Bird TA, Li X.
The Journal of Biological Chemistry 2003 Mar; 278(13):10952.
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IRAK: a kinase associated with the interleukin-1 receptor.
Cao Z, Henzel WJ, Gao X.
Science 1996 Feb; 271(5252):1128.
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Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein.
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