IRAK1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IRAK1.
Immunogen
A synthetic peptide corresponding to human IRAK1.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to IRAK1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using IRAK1 polyclonal antibody (Cat # PAB18514).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — IRAK1
Entrez GeneID
3654Protein Accession#
P51617Gene Name
IRAK1
Gene Alias
IRAK, pelle
Gene Description
interleukin-1 receptor-associated kinase 1
Omim ID
300283Gene Ontology
HyperlinkGene Summary
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000026014|OTTHUMP00000026020|Pelle homolog
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Interactome
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Pathway
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Disease
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Publication Reference
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IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability.
Jensen LE, Whitehead AS.
The Journal of Biological Chemistry 2001 Aug; 276(31):29037.
Application:WB-Ce, WB-Tr, Human, HepG2 cells.
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Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions.
Reichwald K, Thiesen J, Wiehe T, Weitzel J, Poustka WA, Rosenthal A, Platzer M, Stratling WH, Kioschis P.
Mammalian Genome 2000 Mar; 11(3):182.
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IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability.
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