CYP1A2 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against recombinant CYP1A2.
Immunogen
Recombinant protein corresponding to human CYP1A2.
Host
Rabbit
Reactivity
Human
Specificity
Western Blots: Recognizes P450 1A2 in human liver microsomes. Reacts with ≥ 0.2 ug of recombinant human cytochromes P450 1A2. Does not cross react with recombinant human cytochromes P450 2E1, 3A4, or 2C10.
Form
Liquid
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM phosphate buffer, pH 8.0
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Western blot using ECL detection of human CYP1A2 with CYP1A2 polyclonal antibody (Cat # PAB13612). -
Gene Info — CYP1A2
Entrez GeneID
1544Gene Name
CYP1A2
Gene Alias
CP12, P3-450, P450(PA)
Gene Description
cytochrome P450, family 1, subfamily A, polypeptide 2
Omim ID
124060Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq
Other Designations
P450 form 4|aryl hydrocarbon hydroxylase|cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2|dioxin-inducible P3-450|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
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Interactomes
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Pathways
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Diseases
- Abortion
- Adenocarcinoma
- Adenoma
- Amyotrophic lateral sclerosis
- Arrhythmia
- Arthritis
- Asthma
- Attention
- Breast cancer
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Publication Reference
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Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme.
Sandhu P, Guo Z, Baba T, Martin MV, Tukey RH, Guengerich FP.
Archives of Biochemistry and Biophysics 1994 Feb; 309(1):168.
Application:WB-Re, Human, Liver microsomal proteins, Recombinant proteins.
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Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme.
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