ACE2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ACE2.
Immunogen
A synthetic peptide corresponding to internal region of human ACE2.
Host
Rabbit
Reactivity
Human
Specificity
Anti-ACE2 has no cross response to ACE1.
Form
Liquid
Recommend Usage
Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of ACE2 in human kidney tissue lysate with ACE2 polyclonal antibody (Cat # PAB13446) at 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of ACE2 in human kidney tissue with ACE2 polyclonal antibody (Cat # PAB13446) at 2 ug/mL . -
Gene Info — ACE2
Entrez GeneID
59272Protein Accession#
NP_068576Gene Name
ACE2
Gene Alias
ACEH, DKFZp434A014
Gene Description
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Omim ID
300335Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq
Other Designations
ACE-related carboxypeptidase|OTTHUMP00000022963|angiotensin I converting enzyme 2|angiotensin converting enzyme-like protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M.
Nature 2003 Nov; 426(6965):450.
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Angiotensin-converting enzyme 2 is an essential regulator of heart function.
Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Ferrario CM, Manoukian AS, Chappell MC, Backx PH, Yagil Y, Penninger JM.
Nature 2002 Jun; 417(6891):822.
Application:WB-Ti, Rat, Rat kidney.
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A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.
Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S.
Circulation Research 2000 Sep; 87(5):E1.
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Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
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