Product Browser

Last updated: 2014/12/14
  • Related Product Showcase
  • By Disease

Product Compare

Product Compare Cancel Click this icon to add products to compare list. Select up to 10 products.

Quick Order (Tutorial)

Input Catalog #,
place order here!
Catalog # :
  • Where to buy
  • Choose your location

Als2 monoclonal antibody

  • Catalog # : MAB8764
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant Als2.
  • Immunogen:
  • Recombinant protein corresponding to amino acids 221-321 of mouse Als2.
  • Sequence:
  • PSQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQSVATELNAVSAQITSSDAMSS
  • Host:
  • Mouse
  • Reactivity:
  • Mouse
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Concentration:
  • 1 ug/uL
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western blot analysis of Als2 monoclonal antibody (Cat # MAB8764) in mouse neuronal tissue : brain stem (Lane 1), cerebellum (Lane 2) and cortex (Lane 3) transfected with full length Als2-EGFP fusion construct (expected size 220 KDa).
  • Application Image
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Gene Information
  • Gene Name:
  • ALS2
  • Gene Alias:
  • ALS2CR6,ALSJ,FLJ31851,IAHSP,KIAA1563,MGC87187,PLSJ
  • Gene Description:
  • amyotrophic lateral sclerosis 2 (juvenile)
  • Gene Summary:
  • The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • alsin
  • RSS
  • YouTube
  • Linkedin
  • Facebook