F10 monoclonal antibody, clone F10-1
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Specifications
Product Description
Mouse monoclonal antibody raised against F10.
Immunogen
Human F10.
Host
Mouse
Reactivity
Human
Form
Lyophilized
Isotype
IgG1, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
Lyophilized from 10 mM PBS, pH 7.2
Storage Instruction
Store at -20°C.
Aliquot after reconstitution to avoid repeated freezing and thawing. -
Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — F10
Entrez GeneID
2159Gene Name
F10
Gene Alias
FX, FXA
Gene Description
coagulation factor X
Omim ID
227600Gene Ontology
HyperlinkGene Summary
This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq
Other Designations
OTTHUMP00000018735|Stuart-Prower factor|factor Xa|prothrombinase
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Interactomes
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Pathways
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Diseases
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