C-peptide monoclonal antibody, clone C-PEP-01 (Biotin)
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Specification
Product Description
Mouse monoclonal antibody raised against C-peptide.
Immunogen
Human C-peptide conjugated with BSA.
Host
Mouse
Reactivity
Human
Specificity
This antibody reacts specifically with C-peptide, a part of the Proinsulin molecule. Proinsulin consists of the three parts: C-peptide and two long strands of amino acids (alpha and beta chains; later become linked together to form the Insulin molecule). No cross-reactivity with Insulin or other peptide hormones or proteins was observed.
Form
Liquid
Conjugation
Biotin
Isotype
IgG1
Recommend Usage
Immunohistochemistry (25 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Gene Info — INS
Entrez GeneID
3630Gene Name
INS
Gene Alias
ILPR, IRDN
Gene Description
insulin
Gene Ontology
HyperlinkGene Summary
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq
Other Designations
OTTHUMP00000011161|OTTHUMP00000011162|OTTHUMP00000196038|proinsulin
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Publication Reference
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A monoclonal antibody applicable for determination of C-peptide of human proinsulin by RIA.
Hilgert I, Stolba P, Kristofova H, Stefanova I, Bendlova B, Lebl M, Horejsi V.
Hybridoma 1991 Jun; 10(3):379.
Application:RIA, C-peptide fragments.
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A monoclonal antibody applicable for determination of C-peptide of human proinsulin by RIA.
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