Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma. McKee CM, Xu D, Cao Y, Kabraji S, Allen D, Kersemans V, Beech J, Smart S, Hamdy F, Ishkanian A, Sykes J, Pintile M, Milosevic M, van der Kwast T, Zafarana G, Ramnarine VR, Jurisica I, Mallof C, Lam W, Bristow RG, Muschel RJ.J Clin Invest. 2012 Nov 1;122(11):4025-36. doi: 10.1172/JCI59348. Epub 2012 Oct 8.
Western Blot (Transfected lysate)
Western Blot analysis of DHH expression in transfected 293T cell line (H00050846-T01) by DHH MaxPab polyclonal antibody.
Lane 1: DHH transfected lysate(43.56 KDa). Lane 2: Non-transfected lysate.
This gene encodes a member of the Hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq