BAG4 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
BAG4 MaxPab polyclonal antibody. Western Blot analysis of BAG4 expression in human pancreas.
Western Blot (Transfected lysate)
Western Blot analysis of BAG4 expression in transfected 293T cell line (H00009530-T01) by BAG4 MaxPab polyclonal antibody.
Lane 1: BAG4 transfected lysate(50.27 KDa).
Lane 2: Non-transfected lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of purified MaxPab antibody to BAG4 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml]
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human BAG4 protein.
Immunogen
BAG4 (NP_004865.1, 1 a.a. ~ 457 a.a) full-length human protein.
Sequence
MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPISWRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQEQPPYPSYNSNYWNSTARSRAPYPSTYPVRPELQGQSLNSYTNGAYGPTYPPGPGANTASYSGAYYAPGYTQTSYSTEVPSTYRSSGNSPTPVSRWIYPQQDCQTEAPPLRGQVPGYPPSQNPGMTLPHYPYGDGNRSVPQSGPTVRPQEDAWASPGAYGMGGRYPWPSSAPSAPPGNLYMTESTSPWPSSGSPQSPPSPPVQQPKDSSYPYSQSDQSMNRHNFPCSVHQYESSGTVNNDDSDLLDSQVQYSAEPQLYGNATSDHPNNQDQSSSLPEECVPSDESTPPSIKKIIHVLEKVQYLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILEKLEKKGL
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (84); Rat (85)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
BAG4 MaxPab polyclonal antibody. Western Blot analysis of BAG4 expression in human pancreas.Western Blot (Transfected lysate)
Western Blot analysis of BAG4 expression in transfected 293T cell line (H00009530-T01) by BAG4 MaxPab polyclonal antibody.
Lane 1: BAG4 transfected lysate(50.27 KDa).
Lane 2: Non-transfected lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of purified MaxPab antibody to BAG4 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml] -
Gene Info — BAG4
Entrez GeneID
9530GeneBank Accession#
NM_004874Protein Accession#
NP_004865.1Gene Name
BAG4
Gene Alias
BAG-4, SODD
Gene Description
BCL2-associated athanogene 4
Omim ID
603884Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. [provided by RefSeq
Other Designations
BAG-family molecular chaperone regulator-4|silencer of death domains
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Interactome
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Disease
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