MYH9 monoclonal antibody (M06), clone 4H3
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant MYH9.
Immunogen
MYH9 (NP_002464.1, 1871 a.a. ~ 1960 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
RLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDGKADGAEAKPAE
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (94)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (35.64 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to MYH9 on formalin-fixed paraffin-embedded human ovarian cancer. [antibody concentration 0.7 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged MYH9 is approximately 0.03ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to MYH9 on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — MYH9
Entrez GeneID
4627GeneBank Accession#
NM_002473.5Protein Accession#
NP_002464.1Gene Name
MYH9
Gene Alias
DFNA17, EPSTS, FTNS, MGC104539, MHA, NMHC-II-A, NMMHCA
Gene Description
myosin, heavy chain 9, non-muscle
Gene Ontology
HyperlinkGene Summary
This gene encodes a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain. The protein is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in MYH9 are the cause of non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq
Other Designations
MYH9 variant protein|OTTHUMP00000028706|cellular myosin heavy chain, type A|myosin, heavy polypeptide 9, non-muscle|non-muscle myosin heavy chain|non-muscle myosin heavy polypeptide 9|nonmuscle myosin heavy chain II-A
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Interactome
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Pathway
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Disease
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Publication Reference
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EGFR and myosin II inhibitors cooperate to suppress EGFR-T790M-mutant NSCLC cells.
Chiu HC, Chang TY, Huang CT, Chao YS, Hsu JT.
Molecular Oncology 2012 Jun; 6(3):299.
Application:IP, WB-Ce, WB-Tr, Human, H322, H358, H1650, H1975 cells.
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A proteomic study of myosin II motor proteins during tumor cell migration.
Betapudi V, Gokulrangan G, Chance MR, Egelhoff TT.
Journal of Molecular Biology 2011 Apr; 407(5):673.
Application:IF, Human, MDA-MB 231 cells.
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EGFR and myosin II inhibitors cooperate to suppress EGFR-T790M-mutant NSCLC cells.
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