INS monoclonal antibody (M01), clone 3E7
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Specifications
Product Description
Mouse monoclonal antibody raised against a KLH-conjugated peptide spanning 48 ~ 62 amino acid sequence of human Proinsulin.
Immunogen
KLH-conjugated human Proinsulin peptide (NP_000198, 48 a.a. ~ 62 a.a)
Sequence
CFFYTPKTRREAEDLQ
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
ELISA
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Gene Info — INS
Entrez GeneID
3630GeneBank Accession#
NM_000207Protein Accession#
NP_000198Gene Name
INS
Gene Alias
ILPR, IRDN
Gene Description
insulin
Gene Ontology
HyperlinkGene Summary
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq
Other Designations
OTTHUMP00000011161|OTTHUMP00000011162|OTTHUMP00000196038|proinsulin
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Interactomes
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Pathways
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Diseases
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