GOT1 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Western Blot (Tissue lysate)
GOT1 MaxPab polyclonal antibody. Western Blot analysis of GOT1 expression in human liver.
Western Blot (Transfected lysate)
Western Blot analysis of GOT1 expression in transfected 293T cell line (H00002805-T01) by GOT1 MaxPab polyclonal antibody.
Lane 1: GOT1 transfected lysate(45.43 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human GOT1 protein.
Immunogen
GOT1 (NP_002070.1, 1 a.a. ~ 413 a.a) full-length human protein.
Sequence
MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQKIANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLENAPEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGMFSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (91); Rat (90)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
GOT1 MaxPab polyclonal antibody. Western Blot analysis of GOT1 expression in human liver.Western Blot (Transfected lysate)
Western Blot analysis of GOT1 expression in transfected 293T cell line (H00002805-T01) by GOT1 MaxPab polyclonal antibody.
Lane 1: GOT1 transfected lysate(45.43 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — GOT1
Entrez GeneID
2805GeneBank Accession#
NM_002079Protein Accession#
NP_002070.1Gene Name
GOT1
Gene Alias
GIG18
Gene Description
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
Omim ID
138180Gene Ontology
HyperlinkGene Summary
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq
Other Designations
OTTHUMP00000020254|aspartate aminotransferase 1|growth-inhibiting protein 18
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Interactome
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Pathway
- Alanine
- Arginine and proline metabolism
- Biosynthesis of alkaloids derived from ornithine
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Carbon fixation in photosynthetic organisms
- Cysteine and methionine metabolism
- Isoquinoline alkaloid biosynthesis
- Metabolic pathways
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Publication Reference
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Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy.
Nelson BS, Lin L, Kremer DM, Sousa CM, Cotta-Ramusino C, Myers A, Ramos J, Gao T, Kovalenko I, Wilder-Romans K, Dresser J, Davis M, Lee HJ, Nwosu ZC, Campit S, Mashadova O, Nicolay BN, Tolstyka ZP, Halbrook CJ, Chandrasekaran S, Asara JM, Crawford HC, Cantley LC, Kimmelman AC, Wahl DR, Lyssiotis CA.
Cancer & Metabolism 2020 Jan; 8:1.
Application：WB-Tr, Human, MIA PaCa-2 PDA, PA-TU-8902 cells.
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Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy.
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