FGFR2/CEN10p FISH Probe
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Specifications
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: FGFR2
Size: Approximately 330kb
Fluorophore: Texas Red
Location: 10q26Probe 2
Name: CEN10p
Size: Approximately 640kb
Fluorophore: FITC
Location: 10p11.22Probe Gap
The gap between two probes is approximately 91,200 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome. -
Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human breast cancer (FFPE) stained with FGFR2/CEN10p FISH Probe. Left: Human breast cancer showed no FGFR2 gene amplification. Right: Human breast cancer showed FGFR2 gene amplification (FGFR2/CEN10p ratio ≥ 2).Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human stomach carcinoma (FFPE) stained with FGFR2/CEN10p FISH Probe. Human stomach carcinoma showed FGFR2 gene amplification. -
Gene Info — FGFR2
Entrez GeneID
2263Gene Name
FGFR2
Gene Alias
BEK, BFR-1, CD332, CEK3, CFD1, ECT1, FLJ98662, JWS, K-SAM, KGFR, TK14, TK25
Gene Description
fibroblast growth factor receptor 2
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq
Other Designations
BEK fibroblast growth factor receptor|FGF receptor|OTTHUMP00000020621|OTTHUMP00000020629|bacteria-expressed kinase|hydroxyaryl-protein kinase|keratinocyte growth factor receptor|protein tyrosine kinase, receptor like 14|soluble FGFR4 variant 4
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Publication Reference
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3D FISH to analyse gene domain-specific chromatin re-modeling in human cancer cell lines.
Kocanova S, Goiffon I, Bystricky K.
Methods 2018 Jun; 142:3.
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Low Prognostic Implication of Fibroblast Growth Factor Family Activation in Triple-negative Breast Cancer Subsets.
Lee HJ, Seo AN, Park SY, Kim JY, Park JY, Yu JH, Ahn JH, Gong G.
Annals of Surgical Oncology 2014 May; 21(5):1561.
Application:FISH, Human, Triple-negative breast cancer.
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FGFR2 gene amplification and clinicopathological features in gastric cancer.
Matsumoto K, Arao T, Hamaguchi T, Shimada Y, Kato K, Oda I, Taniguchi H, Koizumi F, Yanagihara K, Sasaki H, Nishio K, Yamada Y.
British Journal of Cancer 2012 Feb; 106(4):727.
Application:FISH, Human, Human gastric cancer.
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3D FISH to analyse gene domain-specific chromatin re-modeling in human cancer cell lines.
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