Both DNA and mRNA vaccines deliver the nucleotide sequences that codes for the antigens that the immune system will recognize. These vaccines are designed for the purpose of mimicking a native infection in bodies to trigger immune response, but without the ability to cause disease or spread. Comparing to DNA vaccines, mRNA vaccines do not need to enter the nucleus, eliminating the risk of being integrated into host DNA, and they are directly translated into target antigens. Under the circumstances, mRNA vaccines require only 1/1000 dose of DNA vaccines and do not need special delivery devices.