L1CAM recombinant monoclonal antibody, clone 14H7
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human L1CAM.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human L1CAM.
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography purification
Isotype
IgG
Recommend Usage
ELISA
Flow Cytometry(1:50-1:200)
Immunohistochemistry(1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150 mM NaCl, 0.02% sodium azide and 50% glycerol)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunohistochemistry image of L1CAM recombinant monoclonal antibody, clone 14H7 diluted at 1:50 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system.Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
Overlay Peak curve showing MCF-7 cells stained with L1CAM recombinant monoclonal antibody, clone 14H7 (red line) at 1:50. -
Gene Info — L1CAM
Entrez GeneID
3897Protein Accession#
P32004Gene Name
L1CAM
Gene Alias
CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAML1, S10, SPG1
Gene Description
L1 cell adhesion molecule
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant. [provided by RefSeq
Other Designations
OTTHUMP00000025992|antigen identified by monoclonal antibody R1|neural cell adhesion molecule L1
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Interactome
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Disease
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