Products

Western Blot (Cell lysate)

Western blot analysis of Hela whole cell lysate, 293 whole cell lysate, HepG2 whole cell lysate, NIH/3T3 whole cell lysate, K562 whole cell lysate with STAT6 recombinant monoclonal antibody, clone 2F10 (Cat # RAB07507).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical analysis of paraffin-embedded human kidney tissue using STAT6 recombinant monoclonal antibody, clone 2F10 (Cat # RAB07507) on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

6778

Protein Accession#

P42226

Gene Name

STAT6

Gene Alias

D12S1644, IL-4-STAT, STAT6B, STAT6C

Gene Description

signal transducer and activator of transcription 6, interleukin-4 induced

Omim ID

601512

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. [provided by RefSeq

Other Designations

STAT, interleukin4-induced|signal transducer and activator of transcription 6|transcription factor IL-4 STAT