Products

Western Blot (Cell lysate)

Western blot analysis of A549 whole cell lysate, Hela whole cell lysate, A375 whole cell lysate, HT-29 whole cell lysate, HepG2 whole cell lysate with FURIN recombinant monoclonal antibody, clone 1C3 (Cat # RAB07416).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical analysis of paraffin-embedded human placenta tissue using FURIN recombinant monoclonal antibody, clone 1C3 (Cat # RAB07416) on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

5045

Protein Accession#

P09958

Gene Name

FURIN

Gene Alias

FUR, PACE, PCSK3, SPC1

Gene Description

furin (paired basic amino acid cleaving enzyme)

Omim ID

136950

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq

Other Designations

FES upstream region|dibasic processing enzyme|furin|furin, membrane associated receptor protein|paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein)|proprotein convertase subtilisin/kexin type 3