CTSB recombinant monoclonal antibody, clone R05-1C3
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CTSB.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human CTSB.
Theoretical MW (kDa)
Calculated MW: 38 kD
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:100)
Immunofluorescence(1:50-1:200)
Immunoprecipitation(1:20)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end use.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol and 0.02% Sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunofluorescence
Immunoprecipitation
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Gene Info — CTSB
Entrez GeneID
1508Gene Name
CTSB
Gene Alias
APPS, CPSB
Gene Description
cathepsin B
Omim ID
116810Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
APP secretase|OTTHUMP00000116009|amyloid precursor protein secretase|cathepsin B1|cysteine protease|preprocathepsin B
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Interactome
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