PIAS1/2/3 recombinant monoclonal antibody, clone R04-3J1
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human PIAS1/2/3.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human PIAS1/2/3.
Theoretical MW (kDa)
Calculated MW: 72 kD
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Flow Cytometry (1:50-1:100)
Immunohistochemistry (1:50-1:100)
Immunofluorescence(1:50-1:200)
Immunoprecipitation(1:20)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end use.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol and 0.02% Sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunofluorescence
Immunoprecipitation
Flow Cytometry
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Gene Info — PIAS1
Entrez GeneID
8554Gene Name
PIAS1
Gene Alias
DDXBP1, GBP, GU/RH-II, MGC141878, MGC141879, ZMIZ3
Gene Description
protein inhibitor of activated STAT, 1
Omim ID
603566Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq
Other Designations
AR interacting protein|DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1|protein inhibitor of activated STAT-1|zinc finger, MIZ-type containing 3
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Gene Info — PIAS2
Entrez GeneID
9063Gene Name
PIAS2
Gene Alias
MGC102682, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, miz
Gene Description
protein inhibitor of activated STAT, 2
Omim ID
603567Gene Ontology
HyperlinkGene Summary
This gene encodes a protein involved in the regulation of transcription factors involved in MAP kinase signaling. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq
Other Designations
Msx-interacting-zinc finger|protein inhibitor of activated STAT X|zinc finger, MIZ-type containing 4
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Gene Info — PIAS3
Entrez GeneID
10401Gene Name
PIAS3
Gene Alias
FLJ14651, ZMIZ5
Gene Description
protein inhibitor of activated STAT, 3
Omim ID
605987Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000015586|zinc finger, MIZ-type containing 5
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Interactome
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Pathway
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Disease
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